THE REGULATION OF EXOGENOUS ESTRADIOL IN TRANSCRIPTIONALACTIVITY OF REGENERATING HEPATOCYTES IN RATS
- VernacularTitle:外源性雌二醇对大鼠再生肝细胞转录活性的调节
- Author:
Qianji NING
;
Enzhong LI
;
Xinhui ZHAI
;
Kai WEI
;
Chaokun LI
;
Cunshuan XU
- Publication Type:Journal Article
- Keywords:
Estradiol;
Regenerating hepatocytes;
AgNORs;
Rat
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effect of exogenous estradiol(E-2) on transcriptional activity of regenerating hepatocytes in rats. Methods The E-2 levels in serum were measured using RIA and the numbers of argyrophil nucleolar organizer regions(AgNORs) were investigated. Results Rat serum E-2 level gradually declined after ovariectomy,and no E-2 could be measured after the 15th day.Exogenous E-2 could promote transcriptional activity of regenerating rat hepatocytes,particularly during the first 24h after PH,there was a dose-dependent increase in numbers of AgNORs 24-36h after PH,the exogenous E-2 cause a dose-dependent decrease in numbers of AgNORs,but all of the values were higher than that of control group.Conclusion E-2 can regulate the transcriptional activity of regenerating hepatocytes in rats.
