Advances in prevention and treatment on inflammation and myocardial ischemia-reperfusion injury by PPAR-γ ligands
- VernacularTitle:PPAR-γ配体与炎症、心肌缺血/再灌注损伤防治的研究进展
- Author:
Jingwei LIU
;
Ruijuan XIU
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferator-activated receptor-γ;
Inflammation;
Myocardial ischemia;
Reperfusion
- From:
Chinese Journal of Pathophysiology
2010;26(1):197-199,208
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferation-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily and participates in the regulation of various metabolic pathways as well as inflammatory responses. PPAR-γ ligands significantly improve myocardial functional recovery and prevent ischemia-reperfusion induced injury. Given the increasing understanding of the cardioprotective effects of PPAR-γ ligands, we know today that the therapeutic effects of PPAR-γ ligands reach far beyond their use as insulin-sensitizers, as many of these agents exert beneficial effects in the conditions associated with ischemia-reperfusion and inflammation.
