Pharmacokinetic study of loganin in LIUWEI DIHUANG DECOCTION~* in mice
- VernacularTitle:六味地黄汤中马钱子素小鼠体内药代动力学研究
- Author:
Yuesheng XIE
;
Zhenqing ZHANG
;
Jinxiu RUAN
- Publication Type:Journal Article
- Keywords:
LIUWEI DIHUANG DECOCTION (LWDHD);
loganin;
pharmacokinetics;
HPLC
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the pharmacokinetics of loganin in LIUWEI DIHUANG DECOCTION (LWDHD) in mice. Methods HPLC-UV detection was used to determine the loganin levels in biological samples. Results After ig LWDHD in mice, the plasma concentration-time course fitted well to one-compartment model with the 1st order absorption and with the following pharmacokinetic parameters; Ka= 0.04min -1, Ke=0.019 min -1, T (peak)=42.4 min, t 1/2ka=17.4 min, t 1/2ke=35.75 min. Conclusion The pharmacokinetic parameters of loganin obtained in the study may be attributed to the effect of other constituentsin the DECOCTION.
