Study on nuclear DNA content and image cytometry in cervical cancer and precursor lesions
- VernacularTitle:子宫颈上皮癌前病变及子宫颈癌的细胞核DNA含量图像分析研究
- Author:
Yubing JIAO
;
Xianmei ZHOU
;
Shixiong MA
- Publication Type:Journal Article
- Keywords:
Cervical intraepithelial neoplasia;
Cervix neoplasms;
Image processing, computer assisted
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this research was to study the biological and clinical features of cervical cancer and precursor lesions Methods Nuclear DNA was analyzed by image cytometry (ICM) in 125 embedded tissue 5 ?m sections stained with Feulgen stain Samples included normal cervical squamous epithelium ( n =11), cervical intraepithelial neoplasiaⅠ (CINⅠ) ( n =22), CINⅡ ( n =17) and CINⅢ ( n =13), cervical neoplasm ( n =62) Results The mean DNA content, nuclear area increased progressively from normal cervical epithelium, CINⅠ , CINⅡ , CINⅢ to invasive squamous carcinoma Statistical analysis revealed significant difference ( P
