Inhibitory effects of Yinchenhao Decoction on fatty deposition and TNF-? secretion in HepG2 cells induced by free fatty acid
- VernacularTitle:茵陈蒿汤抗游离脂肪酸对HepG2细胞脂毒性作用的效应中药研究
- Author:
Shaodong CHEN
;
Haihong ZHOU
;
Xuemei LI
;
Jinpei LIN
;
Ying FAN
;
Weijia XU
- Publication Type:Journal Article
- Keywords:
Yinchenhao Decoction;
HepG2 cells;
Hepatic lipotoxicity;
Free fatty acid;
TG;
TNF-?;
Uniform design
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of effective herbs in Yinchenhao Decoction(YD)on fatty deposition and TNF-?secretion of hepatic lipo-toxicity model in vitro.Methods:TG and TNF-?as the inspection target,apply the steatosis with TNF-?secretion lipo-toxicity model in vitro of HepG2 induced by long-chain FFA and uniform design U7(76)form for YD,which had 3 herbs,to compound 6 kinds of different prescriptions,in order to look for the effective herbs or optimized group in YD.Results:The Chinese medicine Yinchen and its optimized group-Yinchen and Zhizi combination can remarkably reduce the TG and TNF-?content.Conclusion:The Chinese medicine Yinchen and its optimized group-Yinchen and Zhizi combination were effective herbs in YD for inhibiting fatty deposition and TNF-?secretion of hepatic lipo-toxicity model in vitro.
