IgG4-related disease of the rectum.
10.4174/astr.2016.90.5.292
- Author:
Sung Bong CHOI
1
;
Chul Hyun LIM
;
Myung Guen CHA
;
Won Kyung KANG
Author Information
1. Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. wonkkang@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Immunoglobulin G;
Plasma cells;
Colonoscopy;
Rectum
- MeSH:
Adult;
Biopsy;
Colonoscopy;
Constipation;
Diagnosis;
Female;
Fibrosis;
Granuloma, Plasma Cell;
Humans;
Immunoglobulin G;
Immunohistochemistry;
Lymphocytes;
Plasma Cells;
Prednisolone;
Proctitis;
Rectum*;
Recurrence;
Ultrasonography
- From:Annals of Surgical Treatment and Research
2016;90(5):292-295
- CountryRepublic of Korea
- Language:English
-
Abstract:
IgG4-related disease is a relatively new disease entity characterized by elevated serum IgG4 levels and marked infiltration of IgG4-positive plasma cells in lesions. Organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs throughout. We encountered a patient with an inflammatory pseudotumor of the rectum, which was histopathologically confirmed to be an IgG4-related disease. The patient was a 28-year-old woman who had constipation for 3 months. The endoluminal ultrasonography showed a lesion that was heterogeneous and low echogenic in lower rectum. The result of colonoscopic biopsy findings was of chronic proctitis with lymphoid aggregates. For a confirmative diagnosis, excision was performed. Histopathological examination represented plasma cell infiltration and fibrosis. Immunohistochemistry revealed prominence of IgG4-positive plasma cells and confirmed the diagnosis of IgG4-related disease. The patient is currently under observation on low-dose oral prednisolone without relapse.
