Effect of preoperative transcatheter arterial chemoembolization for treatment of resectable large hepatocellular carcinoma:a clinical randomized controlled trial
- VernacularTitle:可切除大肝癌术前行与不行肝动脉插管化疗疗效的临床随机对照研究
- Author:
Qinghe TANG
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
hepatocellular carcinoma;
heptatic resection;
transcatheter arterial chemoembolization;
survival rate
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To evaluate the effect of preoperative transcatheter arterial chemoembolization(TACE) on liver function and survival of patients after resection of large hepatocellular carcinoma(HCC) by a randomized controlled approach.Methods: From July 2001 to December 2003,a total of 108 patients with resectable large HCC(≥ 5 cm),who met the inclusion criteria,were prospectively randomized into surgical resection group(OP group,n=56) or preoperative TACE group(TACE+OP group,n=52).Operative outcomes,resection rate,1-,3-,and 5-year tumor-free survival rates and overall survival rate were compared between the two groups.Results: The preoperative baseline conditions were equivalent between the two groups.The ?-globulin level in TACE+OP group was significantly higher than that in the OP group(P=0.046)after chemoembolization.The prealbumin level was significantly lower than that of the OP group seven days after operation(P=0.031).Compared with TACE+OP group,OP group had a significantly higher resection rate(100% vs 89.4%,P=0.017),a less average operative time(P=0.042),and less metastases(2 vs 9,P=0.018).There were no significant differences between the two groups in intraoperative blood loss,warm ischemic time,1-,3-,and 5-year tumor-free survival rates,or overall survival rate.Conclusion: The preoperative TACE can not improve post-operative tumor-free and overall survival rates,and it may result in tumor metastasis or hepatic function damages.
