Gender-related differences of cytochrome P450 3A4 activity
- VernacularTitle:CYP3A4酶介导的人类药物代谢性别差异
- Author:
Yuan GU
;
Duanyun SI
;
Changxiao LIU
- Publication Type:Journal Article
- Keywords:
gender differences;
drug metabolism;
CYP3A4;
in vivo metabolism;
in vitro metabolism;
growth hormone
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Gender-related differences in drug pharmacokinetics have frequently been considered as potentially important determinants for the clinical effectiveness of drug therapy. Major molecular factors involved in drug disposition include drug-metabolising enzymes and drug transporters. Oxidative drug metabolism by cytochrome P450 (CYP) enzymes is a major pathway for drug elimination. CYP3A4,the major human drug-metabolizing CYP enzymes,has repeatedly been suggested higher metabolic activity in women than that in men,which sex-dependent secretory patterns of growth hormone that may be responsible for.
