Expressions of ICAM-1,VCAM-1 and E-selectin in artherosclerosis aorta
- VernacularTitle:动脉粥样硬化病变中黏附分子ICAM-1、VCAM-1及E-selectin的表达
- Author:
Min SU
;
Cuiping ZHONG
- Publication Type:Journal Article
- Keywords:
artherosclerosis;
intercellular adhesion molecule-1;
vascular cell adhesion molecule-1;
E-selectin
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of intercellular adhesion molecule-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1) and E-selectin on the aorta of artherosclerosis and explore the relationship between these molecules and artherosclerosis(AS).Methods Human arterial specimens were collected from 18 cadavers,including 5 with normal arterial tunica intima(control) and 13 with pathologically identified AS(AS group).Analysis were carried out in consecutive sections by immunohistochemical staining for ICAM-1,VCAM-1 and E-selectin.Results ICAM-1,VCAM-1 and E-selectin positive cells were mainly located in the tunica intima and adventitia of AS aorta.More positive cells were observed obviously in AS group than in control(P
