Effects of astragalosides on the expression of BDNF,TrkB and p75NTR mRNA against focal cerebral ischemia-reperfusion injury
- VernacularTitle:黄芪总苷对大鼠局灶性脑缺血/再灌注损伤后BDNF、TrkB和p75NTR mRNA表达的影响
- Author:
Yanyan YIN
;
Weiping LI
;
Weizu LI
;
Huiling GONG
;
Fenfang ZHU
;
Guocui WU
- Publication Type:Journal Article
- Keywords:
astragalosides;
cerebral ischemia;
BDNF;
TrkB;
p75NTR
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the neurological protective effects of astragalosides(AST) on focal cerebral ischemia-reperfusion(I/R) injury in rats and to explore its possible mechanism.Methods Male SD rats received right middle cerebral artery occlusion for 120 min,and were decapitated 1,3,7,and 14 days after reperfusion.AST(40 mg?kg-1) was orally administered after I/R.Neurological deficit score was daily determined,the expressions of BDNF and p75NTR mRNA were detected by RT-PCR,and the expression of TrkB mRNA was detected by real-time PCR.Results AST reduced the neurological deficit score on days 3,increased the expression of BDNF mRNA on days 3,7 and 14,decreased p75NTR mRNA and increased TrkB mRNA on days 3 and 7.Conclusions AST improves the neurological deficits after I/R in rats.The mechanism may be related with increasing BDNF,and TrkB mRNA,and decreasing p75NTR mRNA.
