Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination.
- Author:
Go Eun BAE
1
,
2
;
Nara YOON
;
Ha Young PARK
;
Sang Yun HA
;
Junhun CHO
;
Yunkyung LEE
;
Kyoung Mee KIM
;
Cheol Keun PARK
Author Information
1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yk
2. lee@samsung.com
- Publication Type:Case Report
- Keywords:
Malakoplakia;
Colon;
Kidney transplantation
- MeSH:
Ambulatory Care Facilities;
Basophils;
Biopsy;
Colon;
Colonoscopy;
Cytoplasm;
Eosinophils;
Exudates and Transudates;
Female;
Gastrointestinal Tract;
Histiocytes;
Humans;
Immunocompromised Host;
Immunosuppressive Agents;
Kidney;
Kidney Transplantation;
Lymphocytes;
Malacoplakia;
Plasma Cells;
Polyps;
Transplants
- From:Korean Journal of Pathology
2013;47(2):163-166
- CountryRepublic of Korea
- Language:English
-
Abstract:
Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 microm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
