A Toxicological Study of Polyunsaturated Fatty Acids and Its Application and Research
- VernacularTitle:多不饱和脂肪酸毒理学研究
- Author:
Ying FU
;
Dongying LIU
;
Song MEI
;
Jianguo CHEN
;
Weiqi LAI
;
Yin WANG
- Publication Type:Journal Article
- Keywords:
Polyunsaturated fatty acids;
Acute toxicity;
Heredity toxicity;
Thirty-day feeding test;
Application and research
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide the toxicity basis for safety evaluation of Polyunsaturated Fatty Acids.Methods Acute toxicity test,micronucleus test of born marrow in mice,Ames test,sperm shape abnormality and thirty-day feeding test in rats were conducted in this study.Results The oral LD50 of Polyunsaturated Fatty Acids in both mice and rats were more than 20.0g/kg.BW,so the Polyunsaturated Fatty Acids was classed as actual non-toxicity.The results of micronucleus test of born marrow in mice,Ames test,sperm shape abnormality and thirty-day feeding test in rats were negative.The thirty-day feeding test in rats demonstrated that it had no obvious toxic effects on routine blood,body weight,and biochemical index.No obvious adverse effects dose of this sample was 6.66g/kg.BW.Conclusion Polyunsaturated Fatty Acids toxicity test results showed no obvious toxicity and was safe for edibility.
