Effects of the Velvet Antler Polypeptides on Spinal Nerve Cell Apoptosis Induced by ?-amyloid Peptide
- VernacularTitle:鹿茸多肽对?-淀粉样蛋白诱导脊髓神经元细胞凋亡的保护作用
- Author:
Xukai WANG
;
Ying WANG
;
Yougeng YANG
- Publication Type:Journal Article
- Keywords:
velvet antler polypeptides;
spinal nerve cell;
apoptosis;
?-amyloid peptide;
casepase-3
- From:
Journal of Zhejiang Chinese Medical University
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study effects of the velvet antler polypeptides on spinal nerve cell apoptosis induced by ?-amyloid peptide. [Method]Spinal nerve cells were performed serial subcultivation,and entered into experiment during the exponential phase of growth.The viability of spinal nervecells 24h after induction by ?-amyloid peptide with different concentrations were detected by MTT assay,percentages of the cell apoptosis and expression of casepase-3 were detected after induction by 25?mol/L ?-amyloid peptide.[Result]It was revealed that 24 h after treatment with ?-amyloid peptide of different concentrations,the viability of spinal nerve cells was significantly decreased in a dose-dependent manner(P
