The signal transduction and drug development of epithelial-mesenchymal transition
- VernacularTitle:上皮间质转化的信号转导调控及药物开发
- Author:
Siyun XU
;
Jing LI
;
Meiyu GENG
- Publication Type:Journal Article
- Keywords:
epithelial cell;
mesenchymal cell;
epithelial-mesenchymal-transition;
signaling transduction;
tumor metastasis
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal-transition(EMT) plays a key role in the formation of embryo.At present,it is believed that EMT also contribute to the metastasis of primary tumors.A lot of signaling pathways participate in EMT,such as Wnt/?-catenin,Notch,Hedgehog,TGF? and growth factor receptors.The drugs that affect these pathways may play an important part in oncotherapy.
