Changes of CGRP and NPY expression in tissue-engineered bone with fascia flap
- VernacularTitle:带血管蒂筋膜瓣包裹组织工程骨修复兔桡骨缺损对降钙素基因相关肽和神经肽Y表达的影响
- Author:
Jiande CUI
;
Guoxian PEI
;
Dan JIN
- Publication Type:Journal Article
- Keywords:
tissue engineering;
bone substitutes;
fascia flap;
Calcitonin gene-related peptide;
neuropeptide Y
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expressive levels of calcitonin gene related peptide (CGRP) and neuropeptide Y (NPY) in tissue-engineered bone with fascia flap in vivo. Method A segmental bone defect 1.5cm in length was made at the both radius of 12 healthy New Zealand rabbits. The defects were repaired by implantation in two ways: for left radius, engineered bone with fascia flap was implanted (served as experiment group), and for right radius only engineered bone was implanted (served as control group). 3, 6 and 12 months after implantation, the expressions of CGRP and NPY in the new bone were determined with immunohistochemistry and semi-quantified using image analysis software. Results CGRP and NPY expressions in the both groups were significantly increased in a time-dependent manner (P
