Effects of flavonoids on myocardial apoptosis
- VernacularTitle:黄酮类化合物对心肌细胞凋亡的作用
- Author:
Jin ZHANG
;
Cuicui ZHAO
;
Weina HAN
;
Fengzhi LIU
- Publication Type:Journal Article
- Keywords:
flavonoids;
cardiomyocyte apoptosis;
H_2O_2;
DNA;
bcl-2 family proteins
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of flavonoids,including galangin(G),kaempferol(K),apigenin(A),morin(M),quercetin(Q) and myricetin(MY),on myocardial apoptosis induced by H2O2,and explore the possible mechanism.Methods Primary cultured cardiocytes of neonatal rat were randomly divided into normal group,model group,and flavonoids group.Fluorescent staining,electrophoresis and Western-blot were employed to observe the cardiocyte apoptosis and proteins expression.Results Exposure to 100 ?mol?L-1 H2O2 for 16 h resulted in myocardial apoptosis significantly(P
