Effects of Triptolide on HL-60 Cell in vitro and in vivo
- VernacularTitle:雷公藤内酯醇体内外对HL-60细胞作用的研究
- Author:
Pingli YU
;
Yuanzhong CHEN
;
Jianhua XU
;
Yong WU
;
Xianling CHEN
- Publication Type:Journal Article
- Keywords:
triptolide;
HL-60;
apoptosis;
xenograft of HL-60 cells in nude mice
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of Triptolide (TPL) on HL-60 cells in vitro and in vivo.Methods MTT was used to examine the effects of TPL on proliferation of HL-60 cells;TUNEL assay was used to detect apoptotic cells.The effect of TPL on xenograft growth of HL-60 cells was evaluated by tumor inhibition rate.Results In vitro TPL inhibited the proliferation and induced apoptosis of HL-60 cells in a dose-dependent manner.In vivo TPL inhibited xenograft growth of HL-60 cells with the highest inhibition rate of 53.5%.Conclusion TPL is able to inhibit the proliferation of HL-60 cells and induce apoptosis of HL-60 cells in vitro and in vivo.
