PROLIFERATION INHIBITION AND APOPTOSIS INDUCTION ON HUMAN HEPATO-CARCINOMA HepG-2 CELLS BY UNDARIA PINNATIFIDA POLYSACCARIDES
- VernacularTitle:裙带菜多糖诱导人肝癌HepG-2细胞凋亡的研究
- Author:
Xiangyang ZOU
;
Xue WANG
;
Huaxin WANG
;
Lianying GUO
;
Rong XING
;
Lin HOU
- Publication Type:Journal Article
- Keywords:
Undaria pinnatifida polysaccharides (UPPS);
hepatocellular carcinoma HepG-2 cells;
apoptosis
- From:
Acta Nutrimenta Sinica
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the inhibitory effect of Undaria pinnatifida polysaccharides (UPPS) on hepatocellular carcinoma HepG-2 cells and its possible mechanism. Method: The effect of inhibiting proliferation and inducting apoptosis of UPPS were determined by means of MTT and FCM. The expression of Bcl-2 and Bax proteins was immunohis to chemcally evaluated after treatment of UPPS. Results: UPPS inhibited HepG-2 cells growth in vitro , significantly higher than the negative control group (P
