Effects of metformin on the pitutary-gonad axis calmodulin mRNA expression in rats
- VernacularTitle:二甲双胍对大鼠垂体-性腺轴钙调蛋白mRNA表达的影响
- Author:
Bai KANG
;
Peng DUAN
;
Huirong HAN
;
Chunyan FANG
;
Lin WANG
- Publication Type:Journal Article
- Keywords:
metfomin;
pitutary-gonad axis;
calmodulin
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study effects of metfomin(MF) on calmodulin(CaM) mRNA exprssion of the pitutary-gonad axis in rats.Methods The CaM mRNA expression of the pitutary-gonad axis in rats was measured with the real time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Results MF (270 mg?kg-1?d-1,ig,21 d) significantly inhibited the CaM mRNA expression in testes (P
