Ca~(2+) signaling and pancreatitis
- VernacularTitle:Ca~(2+)信号通道与胰腺炎
- Author:
Zhengang WANG
;
Quanfu XUE
- Publication Type:Journal Article
- Keywords:
Ca2+ signal, pancreatitis;
bile, alcohol;
hyperlipidaemia,caffeine;
acinar cell;
therapeutic targets;
cholecystokinin
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To date, pancreatitis lacks of specific pharmacological therapy. Recently, it has been found that cytosolic Ca2+ overload causes pancreatitis. This article summarized the earliest events of Ca2+ transport in pancreatic acinar cell during pancreatitis and the influence of bile, alcohol, and hyperlipidaemia.Abnormal Ca2+ signal can be inhibited by caffeine. Based on these results, potential therapeutic targets are suggested.
