The trial of hypocaloric parenteral nutrition combined with recombinant human growth hormone in gastrointestinal tumor patients after operation
- VernacularTitle:低热量肠外营养联合生长激素在胃肠道肿瘤病人术后应用的临床研究
- Author:
Pengsheng LI
;
Junsheng PENG
- Publication Type:Journal Article
- Keywords:
Parenteral nutrition;
rhGH;
Gastrointestinal tumor;
Protein metabolism
- From:
Parenteral & Enteral Nutrition
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in protein metabolism after the use of recombinant human growth hormone(rhGH) in gastrointestinal tumor patients after operation.Methods:Thirty-nine patients with gastrointestinal tumor were randomly(double-blind) divided into two groups: ①the control group(n=20),which was treated with hypocaloric parenteral nutrition and placebo,②the rhGH group(n=19),which was treated with hypocaloric parenteral nutrition and rhGH.The levels IGF-1 and protein metabolism were observed.Results:The concentrations of IGF-1,pre-albumin,transferrin and fibronectin were decreased in the two groups on the 3th day after operation.The administration of rhGH resulted to significant increase in serum levels of IGF-1,pre-albumin,transferrin and fibronectin.Conclusion:The administration of recombinant human growth hormone can increase the protein synthesis and improve the nutritional condition.
