Serum expression of monocyte chemoattractant protein-1 and macrophage inhibitory protein-1? in patients with rheumatoid arthritis
- VernacularTitle:类风湿关节炎患者血清趋化因子MCP-1、MIP-1?的表达
- Author:
Jun BAO
;
Huiqi LU
;
Huji XU
- Publication Type:Journal Article
- Keywords:
arthritis,rheumatoid;
monocyte chemoattractant protein-1;
macrophage inhibitory protein-1?
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the possible role of chemokines monocyte chemoattractant protein-1(MCP-1) and macrophage inhibitory protein-1(MIP-1?) in pathogenesis of rheumatoid arthritis(RA).Methods: Enzyme linked immunosorbent assay(ELISA) was used to determine the serum expression of MCP-1 and MIP-1? in 17 patients with early active RA,18 with advanced active RA,and 15 healthy controls(all aged 18-79 years).Clinical activity indices such as the strength of grip,joint pain index,and joint swelling index were assessed in all subjects;and the serological indices such as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),and rheumatoid factors were also determined.The relationships between serum levels of MCP-1, MIP-1? with the clinical activity indices and serological indices were analyzed.Results: The serum levels of MCP-1 in patients with early and advanced RA were higher than that in the controls(P
