Effect of rosiglitazone on insulin sensitivity and ?-cell function in polycystic ovary syndrome patients with insulin resistance
- VernacularTitle:罗格列酮对多囊卵巢综合征患者胰岛素敏感性和?细胞功能之改善
- Author:
Xiaosu BAI
- Publication Type:Journal Article
- Keywords:
rosiglitazone;
polycystic ovarian syndrome;
glucose clamp technique;
insulin resistance;
?-cell function
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To explore the effect of rosiglitazone on the insulin sensitivity and ?-cell function in polycystic ovary syndrome(PCOS)patients accompanied with insulin resistance.Methods Rosiglitazone was given to 15 patients PCOS with insulin resistance at a dose of 4 mg daily for 12 weeks.All patients underwent an oral glucose tolerance test and Botnia clamp,and their body mass index(BMI),waist/hip ratio(WHR),serum pressure,follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone,free testosterone(FT),glucose and insulin were determined and compared before and at the end of the treatment.Results After 12 weeks' treatment,Waist/Hip ratio,FT and LH/FSH ratio,and fasting insulin were significantly decreased(P
