A novel therapy for PD-adenosine A_ (2A) receptor antagonist
- VernacularTitle:治疗帕金森病新药:腺苷A_(2A)受体拮抗剂
- Author:
Dan ZHANG
;
Jianjun ZHANG
;
Gengtao LIU
- Publication Type:Journal Article
- Keywords:
adenosine A_ 2A receptor;
Parkinsons disease;
dyskinesia;
neuroprotection
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine A_ 2A receptors are selectively localized in basal ganglia and can affect the locomotor activity. Epidemiological and laboratory data have suggested that A_ 2A blockade may confer neuroprotection against the underlying dopaminergic neuron degeneration. A_ 2A receptor antagonist may ameliorate the symptom of Parkinsons disease (PD) and block the disease progress. Thus, the data suggested that A_ 2A receptor antagonist might be effective as a novel therapy for the management of PD.
