Neutrophil elastase: a target of neuroprotection
- VernacularTitle:中性粒细胞弹性蛋白酶——神经保护的作用新靶点
- Author:
Fanxin ZENG
- Publication Type:Journal Article
- Keywords:
neutrophil;
elastase;
brain injury;
inflam-matory response;
cerebral ischemia/reperfusion;
in-tracerebral hemorrhage
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Tissue or organic injuries(especially induced by ischemia/reperfusion) are often followed by inflammatory response characterized with neutrophil infiltration.Neutrophils exacerbate tissue or organic injuries by releasing elastase.Since brain injuries induced by cerebral ischemia/reperfusion,intracerebral hemorrhage,cerebral trauma also accompany infiltration of neutrophil,and elastase derived from neutrophil probably plays an important role in brain injury.
