Effects of chloride channel blocker on hypoxia induced rat pulmonary hypertension
- VernacularTitle:氯离子通道阻断剂对大鼠低氧性肺动脉高压的影响
- Author:
Biwen MO
;
Jinrong ZENG
;
Guojian LI
;
Wenxin HUANG
;
Fang YU
;
Jiying WANG
;
Changming WANG
- Publication Type:Journal Article
- Keywords:
tamoxifen;
hypoxia pulmonary hypertension;
hypoxia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the therapeutic effect of chloride channel blocker tamoxifen on hypoxia pulmonary hypertension in rats.METHODS: Sixty male Wistar rats were randomly divided into therapeutic group(H/Q group),hypoxia group(H group),normal control group(C group).Mean pulmonary artery pressure(mPAP),the ratio of the weight of right ventricle to that of left ventricle plus septum[RV(LV+S)],and the ratio of the pulmonary arteriole wall area to that of vascular total area(WA/TA),were measured at 4,7,14,21 days.RESULTS:The mPAP began to increase from 7 days,and reached peak at 21 days in hypoxia group,however it is obviously lower in therapeutic group at same time.The ratio of RV(LV+S) began to increase from 14 days,and reached peak at 21 days in hypoxia group,however it is obviously lower in therapeutic group at same time.The ratio of WA/TA at 21 days in hypoxia group was significantly higher than therapeutic group,respectively(P
