Anti-LPS antibody and antibiotic treatment in burns
- VernacularTitle:抗内毒素抗体治疗严重烧伤内毒素血症29例
- Author:
Haijian LU
;
Junci XU
;
Hong MENG
;
Xiangjing FANG
;
Qiming CHEN
- Publication Type:Journal Article
- Keywords:
Burns;
Endotoxemia;
Antibiotics,combined;
Antibodyies,bacterial
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effect of anti-LPS antibody and different antibiotic in treatment and prevention of sepsis a common complication of serious burns.Methods Twenty-nine patients were divied into anti-LPS+antibiotic treatment group and antibiotic treatment group.Plasma endotoxin,serum TNF,IL-6 and IL-8 were detected at different time phase after burn.Results The results showed that the antibodies to LPS could decrease the level of LPS,IL-6,IL-8 and TNF obviously,but some antibiotic couldn't decrease the level of LPS,IL-6,IL-8 and TNF obviously in blood.Impenem was a weak endotoxin inducer and ceftazidime and ciprofloxacin were stronger endotoxin inducers.Conclusion The appropriate selection of antibiotics and anti-LPS antibody has a considerable influence on treating sepsis and its complications after serious burns.
