Reverse effects of zoledronic acid on the malignant phenotype of Bel-7402 human hepatocancinoma cells
- VernacularTitle:唑来膦酸诱导Bel-7402人肝癌细胞分化的研究
- Author:
An PENG
;
Minzhen CHEN
;
Donglan SHEN
- Publication Type:Journal Article
- Keywords:
Zoledronic acid;
Hepaticarcinoma cells;
Differentiation of cell
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the reverse effects of zoledronic acid on the malignant phenotype of Bel-7402 human hepatocarcinoma cells.Methods The AFP secretary amount of the cells was determind with RIA,and thespecfic activities of tyrosine-?-ketoglutarate transaminase(TAT),ornithine carbamyl transferase(OCT) and alkaline phospharase(ALP),?-glutamgl transpeptidase(?-GT) and aldolase(ALD) were assayed by enzymological methods.Results Treating with 0.05?g/ml zoledronic acid,the proliferation of the cells,the secretary amount of AFP,and the specific activities of ?-GT and ALD significantly decreased(P
