Effects of Panax Notoginseng Saponins on expression of Caspase after focal cerebral ischemia-reperfusion in rats
- VernacularTitle:三七总皂苷对大鼠脑缺血再灌注后Caspase表达的影响
- Author:
Hua LI
;
Changqing DENG
;
Beiyang CHEN
;
Ruifen CHEN
;
Shuping ZHANG
;
Yan LIANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia-reperfusion;
rat;
panax notoginseng saponins;
Caspase-1;
Caspase-3;
Caspase-8
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of Panax Notoginseng Saponins(PNS) on expressions of Caspase-1,Caspase-3 and Caspase-8 after transient focal cerebral ischemia-reperfusion(CIR).Methods CIR injury was induced by middle cerebral artery occlusion(MCAO) in rats.The rats were treated with PNS(25 mg?kg~(-1)) and Nimodipine(1 mg?kg~(-1)).The drugs were administered 5 min before cerebral ischemia,and 12,24 and 36 h after cerebral ischemia.Sham operation group and model group were givenequal volume normal saline.The expressions of Caspase were observed by using immunochemistry after cerebral ischemia for 2 h followed by reperfusion for 46 hours.Results The expressions of Caspase-1 and Caspase-3 protein increased after cerebral ischemia.PNS decreased the expressions of Caspase-1(P
