Protective effects of L-Carnitine on the kidney damage induced by cisplatin in rats
- VernacularTitle:左旋肉碱对顺铂损伤大鼠肾的保护作用
- Author:
Heng JIANG
;
Baoquan JIANG
- Publication Type:Journal Article
- Keywords:
L-Carnitine;
Cisplatin;
Kidney;
Lipid peroxidation
- From:
Parenteral & Enteral Nutrition
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the protective effects of L-Carnitine(LC) against the kidney damage induced by cisplatin(DDP).Methods: 36 Female adult Wistar rats were randomly divided into Control group,DDP group and LC+DDP group.Control group and DDP group were fed a basic diet,while LC+DDP group were added 1%LC.After 7 days,DDP group and LC+DDP group received cisplatin i.p.(5 mg/kg body weight),while Control group received normal saline i.p.After 4 days,rats were killed,the change of serum Cr and BUN,and tissue MDA and GSH in kidney were measured and the kidney structure was also observed.Results: Compared with DDP group,the contents of serum Cr、BUN and kidney tissue MDA of LC+DDP group declined very significantly,while the contents of kidney tissue GSH increased significantly.The pathological slice indicated that the renal structure of LC+DDP group was significantly improved.Conclusion: Dietary supplementation with LC might protect kidney against the damage induced by cisplatin in some extent,which might be partially correlative with the antioxidative effects of LC.
