On Changes of Activity of Antioxidases in Hippocampus of Rats with Multi-Infarct Dementia and the Intervention Effects of Acupuncture
- VernacularTitle:多发梗塞性痴呆大鼠海马抗氧化酶活性的变化及针刺的干预作用
- Author:
Cunzhi LIU
;
Jianchun YU
;
Xuezhu ZHANG
- Publication Type:Journal Article
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the changes of activity of antioxidases in hippocampus of the rats with multi-infarct dementia and the intervention effects of acupuncture.Method: The multi-infarct dementia model was made by injected emboli into the internal carotid artery.The demented rats were allocated to 3 groups randomly: model,acup and sham-acup;meanwhile normal and sham-operated rats were used as control.The parameters of oxidative stress were assessed by measuring the malondialdehyde(MDA),superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GSH-Px) levels in hippocampus after acupuncture treatment.Result: Compared to normal group,MDA levels of hippocampus in model animals increased significantly,while SOD and GSH-Px decreased much more;No significant difference was observed in CAT among groups.Interestingly,the acupuncture treatment could significantly improve all those indexes.Conclusion: SOD/GSH-Px pathway may be playing a major role in combating oxidative stress in the brain of MID rats,the CAT activity not the key enzyme.Acupuncture treatment could increase the activity of antioxidase SOD/GSH-Px,alleviate the injury of free radical and maintain the oxidant-antioxidant balance to a great extent.This may be one of the mechanisms of its therapeutic effect.
