Study on the expression of ?-SMA in rats with adriamycin-induced nephrothy and intervention of Valsartan on it
- VernacularTitle:阿霉素肾病大鼠?-SMA表达特点及缬沙坦的干预治疗
- Author:
Yueling DING
;
Yingjun DING
;
Yuyong ZHAO
- Publication Type:Journal Article
- Keywords:
adriamycin-induced nephrothy;
valsartan;
cell phenotype conversion;
quantitative analysis
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the changes on the expression of ?-SMA in rats with adriamycin-induced nephrothy and intervention of Valsartan. Methods The model group were made by unilateral nephrectomy with twice-adriamycin injections by caudal vein. Immunohistochemical method, flow cytometry and pathologic image analysis were used to observe the expression of ?-SMA, FN and LN in rats. Results The expression of ?-SMA was positive in the model group. Rates of positive cell and protein semi-quantitative analysis were more higher than the sham group(P
