Dengue 2 virus induces molecular alteration in the coagulant and fibrinolytic pathways of human umbilical vein endothelial cells
- VernacularTitle:登革病毒诱导血管内皮细胞凝血和纤溶系统相关分子变化
- Author:
Xiaolong TANG
;
Shuyu CAI
;
Zhenyou JIANG
;
Lifan JIANG
- Publication Type:Journal Article
- Keywords:
dengue virus;
tissue plasminogen activator;
plasminogen activator inhibitor 1;
thrombomodulin;
interleukin 6
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and soluble thrombomodulin (sTM) induced by dengue 2 virus (D 2V) infection of vascular endothelial cells. Methods The effects of D 2V infection on the production of t-PA, PAI-1, and sTM of human umbilical cord vein cells were studied. Results D 2V infection significantly induced the secretion of sTM and t-PA but showed no such effects on PAI-1 of human endothelial cells. Antibody against IL-6 inhibited D 2V-induced t-PA production of endothelial cells. A close correlation between serum levels of IL-6 and t-PA was found in dengue hemorrhagic fever (DHF) but not in dengue fever (DF) patients. Conclusion IL-6 can regulate D 2V-induced t-PA production of endothelial cells, suggesting that endothelial cells can be the target for D 2V infection and that D 2V-induced t-PA, TM, and IL-6 production of endothelial cells may contribute to the pathogenic development of dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS).
