Effect of PD on the activity of protein kinase c of vascular smooth muscle cells
- VernacularTitle:虎杖苷对缺血缺氧下平滑肌细胞蛋白激酶C的影响
- Author:
Yuegang WANG
;
Chunhua JIN
;
Haixiao HUANG
;
Qing ZHAO
;
Pingsheng WU
- Publication Type:Journal Article
- Keywords:
ischemia;
hypoxia;
vascular smooth muscle cells;
protein kinase C;
polydatin
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the influence of PD on the activity of PKC(protein kinase C) of VSMC during ischemia and hypoxia.Methods The hypoxia model was made by drawing off the oxygen of an enclosed acryl glass box and ischemia model was made by low sugar culture medium. Then the activity of PKC was measured by ?-scintillation counting instrument.Results It was found that the activity of PKC of cytoplasm in VSMC in ischemia and hypoxia situation increased (vs normal group P0.05 ).Conclusion PD can reverse the PKC activities induced by ischemia and hypoxia. It may be one of the mechanisms of PD to have antishock effect.
