Curative effect of interferon gamma on pulmonary fibrosis in rats and the mechanisms
- VernacularTitle:干扰素?对实验大鼠肺纤维化的治疗作用及机制的初步研究
- Author:
Xiaofang GAO
;
Shehuai CUI
- Publication Type:Journal Article
- Keywords:
interferon gamma;
pulmonary fibrosis;
bolemycin
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of interferon gamma (IFN-?) on pulmonary fibrosis induced by bleomycin in rats and the related mechanisms. Methods A total of 90 rats were randomly divided into 3 groups (n=30 in each group): normal control group, pulmonary fibrosis group, and IFN-? treated group. On days 1, 3, 7, 14, and 28 after bolemycin treatment, 6 rats in each group were sacrificed. PO 2 was determined. The lungs and serum were collected for histopathological and electron microscopic examinations. The contents of transforming growth factor ? 1 (TGF-? 1) and fibronectin (FN) were determined by immunohistochemistry, and the contents of IL-4 and surfactant protein A (SP-A) were detected by ELISA and Western blotting, respectively. Results PO 2 level increased significantly (P
