Cyclooxygenase 2 expression in neonatal rats contributes to hypoxic-ischemic brain damage
- VernacularTitle:新生大鼠脑缺氧缺血损伤时的COX-2表达变化
- Author:
Enyi WEN
;
Congmin ZHAO
;
Liyan WANG
;
Yuping ZHANG
- Publication Type:Journal Article
- Keywords:
hypoxic-ischemic brain damage;
cyclooxygenase 2;
immunohistochemistry;
neonatal rat
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cyclooxygenase 2 (COX-2) in neonatal rats after hypoxic-ischemic brain damage (HIBD). Methods A model of HIBD in the left brain of 7-day-old Wistar rats was established. The ischemic cortex was sampled for analysis at 2, 6, 24, and 72 h, and 7 d after the onset of hypoxic-ischemic damage. The expression and number of the positive cells of COX-2 in the cortex and hippocampus at different time points were observed by immunohistochemistry. Results Low level of COX-2 immunohistochemical expression was observed in the control group. COX-2 positive cells were upregulated in ischemic brain at 2 h and peaked between 6-24 h significantly (P
