Impact of Serum Triglyceride and High Density Lipoprotein Cholesterol Levels on Early-Phase Insulin Secretion in Normoglycemic and Prediabetic Subjects.
10.4093/dmj.2014.38.4.294
- Author:
Masanori SHIMODAIRA
1
;
Tomohiro NIWA
;
Koji NAKAJIMA
;
Mutsuhiro KOBAYASHI
;
Norinao HANYU
;
Tomohiro NAKAYAMA
Author Information
1. Department of Internal Medicine, Iida Municipal Hospital, Iida, Japan. masanori19810813@yahoo.co.jp
- Publication Type:Original Article
- Keywords:
Cholesterol, HDL;
Diabetes;
Insulin secretion;
Triglycerides
- MeSH:
Asian Continental Ancestry Group;
Cholesterol, HDL*;
Fasting;
Glucose;
Glucose Tolerance Test;
Hand;
Humans;
Insulin*;
Linear Models;
Triglycerides*
- From:Diabetes & Metabolism Journal
2014;38(4):294-301
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Increased triglycerides (TGs) and decreased high density lipoprotein cholesterol (HDL-C) levels are established as diabetic risks for nondiabetic subjects. The aim of this study was to investigate the relationship among TG, HDL-C, TG/HDL-C ratio, and early-phase insulin secretion in normoglycemic and prediabetic subjects. METHODS: We evaluated 663 Japanese subjects who underwent the 75-g oral glucose tolerance test. On the basis of these results, the subjects were divided into four groups: those with normal glucose tolerance (NGT; n=341), isolated impaired fasting glucose (i-IFG; n=211), isolated impaired glucose tolerance (i-IGT; n=71), and combined IFG and IGT (IFG+IGT; n=40). Insulin secretion was estimated by the insulinogenic index (IGI) (Deltainsulin/Deltaglucose [30 to 0 minutes]) and disposition index (DI) (IGI/homeostasis model assessment of insulin resistance). RESULTS: In prediabetic subjects (i-IFG, i-IGT, and IFG+IGT), linear regression analyses revealed that IGI and DI were positively correlated with HDL-C levels. Moreover, in subjects with i-IGT and (IFG+IGT), but not with i-IFG, the indices of insulin secretion were negatively correlated with the log-transformed TG and TG/HDL-C ratio. In both the subjects with i-IGT, multivariate linear regression analyses revealed that DI was positively correlated with HDL-C and negatively with log-transformed TG and TG/HDL-C ratio. On the other hand, in subjects with NGT, there was no association between insulin secretion and lipid profiles. CONCLUSION: These results revealed that serum TG and HDL-C levels have different impacts on early-phase insulin secretion on the basis of their glucose tolerance status.
