Inhibitory effect of soybean isoflavone genistein on renal TGF-?_1 in rats with unilateral ureteral obstruction
- VernacularTitle:大豆异黄酮对UUO大鼠TGF-?_1的抑制作用
- Author:
Lixin TENG
;
Jing ZHANG
;
Shengxue LIU
;
Ji CAO
- Publication Type:Journal Article
- Keywords:
renal interstitial fibrosis;
genistein;
unilateral ureteral obstruction;
transforming growth factor-? 1
- From:Journal of Third Military Medical University
2003;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effect of soybean isoflacone genistein on rats with unilateral ureteral obstruction (UUO) and the related mechanisms. Methods Rats were randomly divided into the following groups: sham-operation (group S, n=18), UUO group (group C, n=30), and geinstein treatment group (group G, n=42, at the dose of 200 mg?kg -1 ?d -1 ). At 5, 10, 15, 20, 25, and 30 d after operation, the pathological changes of the ligated kidneys were observed and the expression of mRNA of TGF-? 1 in renal tissues was examined by RT-PCR. Results Genistein treatment significantly reduced the section percentage of interstitial fibrosis in ligated kidneys at different time after operation (P
