Contribution of imidazoline receptors in caudal ventrolateral medulla to central depressor effect of clonidine
- VernacularTitle:尾端延髓腹外侧区咪唑啉受体在可乐定中枢降压效应中的作用
- Author:
Wensheng CHEN
;
Sheng SHI
;
Weizhong WANG
;
Wenjun YUAN
- Publication Type:Journal Article
- Keywords:
clonidine;
central depressor action;
blood pressure;
I1-imidazoline receptor;
caudal ventrolateral medulla
- From:
Academic Journal of Second Military Medical University
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the roles of the caudal ventrolateral medulla(CVLM) in the central anti-hypertensive mechanism. Methods : In 20 urethane-anesthetized SD rats, the effects of I1-imidazoline receptor and ?2-adrenceptor antagonists (microinjection into the CVLM) on the cardiovascular responses induced by intravenous clonidine were observed. Results: Prior bilateral microinjection of mixed antagonist idazoxan (I1-imidazoline receptor and a2-adrenceptor) into the CVLM not only decreased the mean arterial pressure [(-17. 3 ? 6. 9) mmHg, 1 mmHg = 0. 133 kPa, P
