The role of serotonin in ventrolateral preoptic area on sleep-wakefulness cycle of rat
- VernacularTitle:腹外侧视前区5-羟色胺对大鼠睡眠-觉醒周期的作用
- Author:
Gongliang ZHANG
;
Yanlong HE
;
Liecheng WANG
;
Lezhang ZHAO
;
Jing ZHANG
;
Mingkui ZHONG
;
Jingxing ZHANG
- Publication Type:Journal Article
- Keywords:
ventrolateral preoptic nucleus (VLPO);
serotonin;
slee p;
wakfulness
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the role of serot on in (5-HT) in ventrolateral preoptic nucleus(VLPO) on sleep and wakefulness cycl e of rat by microinjection of 5-hydroxytryptaphan (5-HTP , precursor of 5-HT ) , non-special 5-HT receptor antagonist methysergide (MS) and 5-HT retake i nhibitor fluoxetine. METHODS Stereotaxic, microinjection and po lysomnography (PSG) were used in the experiment. RESULTS There was no significant effect by microinjection of 5-HTP(0 5 ?g,0 1 ?l) into VLPO,but microinjection of 5-HTP(1 ?g,0 1 ?l)and fluoxetine lead wake i ncreased and sleep decreased; while microinjection of non-selective serotonin receptor antagonist MS lead to the opposited effect. The chang of sleep-wakefu lness cycle caused by 5-HTP or MS were significantly assiociated with time. CONCLUSION 5-HT involved in the regulation of sleep-wake cycle a nd promoted wake in the VLPO and its role of promotion may involve the gene exp ression of post-synaptic neurons.
