Relationship between preoperative plasma D-dimer level and the lymph-node metastasis characteristics in colorectal cancer patients

VernacularTitle:结直肠癌术前D-二聚体水平与淋巴结转移的关系
Author: Lin XU ; Kaiqin PENG
Publication Type:Journal Article
Keywords: Colorectal cancer; D-dimer; The lymph-node metastasis
From: International Journal of Surgery 2013;40(7):454-456,封3
CountryChina
Language:Chinese
Abstract: Objective To determine the relationship between preoperative plasma D-dimer level and the lymphnode metastasis characteristics in colorectal cancer patients.Methods A total of 106 patients with colorectal cancer were studied in order to evaluate this relationship.Their preoperative plasma D-dimer levels were measured.Results were correlated with the clinicopathological findings.Results Significantly different plasma D-dimer levels were found with respect to histologic N(P ＜ 0.001).The number of lymph node metastases was found to have the strongest association with D-dimer level among the significant clinicopathologic factors (Spearman rank correlation,P ＜0.001).The most useful cutoff of the plasma D-dimer levels for diagnosis of lymph node metastasis was determined to be 0.4 μg/mL.Conclusion Plasma D-dimer levels can help assess lymph node metastasis in patients with eophageal cancer and should be measured preoperatively.