THE EFFECT OF BENAZEPRIL ON PRODUCTION OF NITRIC OXIDE AND ANGIOTENSIN IN SPONTANEOUS HYPERTENSION IN RAT
- VernacularTitle:贝那普利对自发性高血压大鼠血管组织一氧化氮和血管紧张素的影响
- Author:
Liufa DUAN
;
Qiufu ZHENG
;
Liping ZHANG
- Publication Type:Journal Article
- Keywords:
benazepril;
rats, inbred SHR;
nitric oxide;
angiotensin
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the changes in nitric oxide (NO) and angiotensin (AⅡ) in rat with spontaneous hypertension (SHR) and the effect of benazepril on production of NO/AⅡ. The animals were divided into three groups: normotensive (WKY) group, SHR control group and benazepril group. Blood pressure was measured by the tail-cuff method. NO - 3 concentration in serum was assayed by activated cadmium reduction method; cGMP and AⅡ levels in vascular tissue were assayed by RIA (radioimmunoassay). The results showed that blood NO - 3 concentration and vascular cGMP level were all lower in SHR group compared with WKY rats(P
