The clinical efficacy of adefovir dipivoxil combined with reduced glutathione therapy for decompensated hepatitis B cirrhosis
10.3969/j.issn.1671-8348.2014.09.025
- VernacularTitle:阿德福韦酯联合还原型谷胱甘肽治疗失代偿期乙型肝炎后肝硬化的疗效观察
- Author:
Mingque XIANG
;
Jing PAN
;
Maorui HE
;
Hong YANG
;
Linghua XIE
;
Yongping CAO
- Publication Type:Journal Article
- Keywords:
glutathione;
liver cirrhosis;
adefovir dipivoxil
- From:
Chongqing Medicine
2014;(9):1093-1094,1097
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficay of the therapy adefovir dipivoxil combined with reduced glutathione in the treatment of decompensated hepatitis B cirrhosis .Methods 76 cases of decompensated hepatitis B cirrhosis were divided into the treatment group and the control group ,38 cases in each group .Both groups take symptomatic and supportive treatment ,the obser-vation group plus adefovir dipivoxil combined with glutathione therapy .After 3 months treatment ,we observed liver function ,hepa-titis B virus DNA quantification and assessed the clinical efficacy .Results After treatment ,the treatment group liver function im-proved was significantly better than the control group (P<0 .05) ,the total effective rate was higher than the control group (P<0 .05) ,the rate of hepatitis B virus DNA turn to negative was significantly higher than the control group (P<0 .01) .Conclusion Adefovir dipivoxil combined with reduced glutathione therapy for decompensated hepatitis B cirrhosis can effectively improve liver function ,suppress hepatitis B virus DNA undetectable ,reduce the incidence of the complication ,and worthy of promote in our clini-cal practice .
