Effect of vesnarinone on PKC activity and NO content on myocardial injury induced by ischemia and reperfusion in rats
- VernacularTitle:维司力农对缺血再灌注大鼠心肌NO含量及PKC活性的影响
- Author:
Wenli XIE
;
Jiang ZHU
;
Yuzhang JIN
- Publication Type:Journal Article
- Keywords:
vesnarinone;
ischemic preconditioning;
oxide nitric;
protein kinase C
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protective effects of vesnarinone on myocardial ischemia. METHODS Rat myocardial oxide nitric (NO) content, protein kinase C (PKC) activities in different groups were determined by kits. RESULTS Vesnarinone 1 mg?kg -1 or 2 mg?kg -1 iv markedly improved the NO content and PKC activity before ischemia for 30 min and reperfusion for 2 h in rats. CONCLUSION Vesnarinone possesses a protective effect against myocardial ischemia via NO induce PKC.
