CHARACTERISTICS AND CLINICAL IMPLICATION OF HIV-1 CORECEPTOR CX_3CR1 ALLELIC POLYMORPHISM IN UIGUR ETHNIC GROUP FROM SINKIANG UIGUR AUTONOMOUS REGION
- VernacularTitle:维吾尔族人群CX_3CR1基因多态性特征及其意义
- Author:
Mingxu LIU
;
Fusheng WANG
;
Jin HOU
- Publication Type:Journal Article
- Keywords:
HIV 1 coreceptor;
CX 3 CR1;
allelic polymorphism
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
It was reported that 249I 280M haplotype of HIV coreceptor CX 3 CR1 was associated with accelerated AIDS progression. In this study, genomic DNA of 119 Uigur subjects (98 normal, 21 HIV 1 infected) was purified from PBMC, and 249I and 280M allelic frequencies were identified by PCR RFLP. All data were tested by ? 2 analysis.It was found that allelic frequency of 249I and 280M was 15 8% and 13 8%, respectively, and there was no difference between normal and HIV infected groups. Both population and sex distribution were in accordance with Hardy Weinberg equilibrium. Frequency of 249I280M haplotype was 13 8%, close to that of Caucasian people. No linkage was found between CX 3 CR1 and CCR5?32, but strong linkage existed between 249I and 280M ( P
