Effects of doxorubicin on IL-2 release and LAK activity of human fetal thymocytes
- VernacularTitle:阿霉素对人胚胸腺细胞IL-2产生及LAK活性的影响
- Author:
Tihui FU
;
Zhirong XIE
;
Bifang DENG
- Publication Type:Journal Article
- Keywords:
doxorubicin;
human fetal thy-mocyte;
IL-2;
LAK activity
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The immunoregulatory effects of some anti-cancer drugs have important role in their anti-tumor mechanisms. Our results showed that doxorubicin (DXR) of 0.04 mg ?L-1 could enhance the interleukin 2 (IL-2) release and induction of lymphokine-activated killer (LAK) activity of human fetal thymocytes(HFT). Higher concentration of this drug (4 mg ?L-1) exhibited inhibition on IL-2 release but no effect on LAK activity. These data suggest that lower concentration of DXR have some immunopotentiation effects on HFT.
