Study on Hypoglycemic Activity of Alkaline Extract from cultural Mycelium of Cordyceps sinensis
- VernacularTitle:人工虫草碱提取物的降血糖作用研究
- Author:
Hui JI
;
Honghu TU
;
Naisan LI
;
Guoqing LIU
- Publication Type:Journal Article
- Keywords:
cultural mycelium of Cordyceps sinensis;
blood glucose level;
diabetes mouse;
hypoglycemic activity
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The dried powder of cultural mycelium of ordyceps sinensis was extractedwith 1.25 mol ? L-1sodium hydroxide and precipitated with ethanol to afford the CsOH, in 2.58% yield. CsOH was consisted of 5 monosaccharide measured by paper chromatogra-phy (PPC) and gas- liquid chromatography (GLC). CsOH given intragastrically at the dose of 500 mg?kg-1and 250 mg?kg-1,ip at a dose of 100 mg?kg-1and 50 mg?kg-1had significant hypoglycemic activities in normal mice, alloxan-induced diabetes mice and streptozotocin-induced diabetes mice, and showed a dose-effect relation.
