Effect of interleukin-8 on rat intestinal ischemia-reperfusion injury
- VernacularTitle:白细胞介素-8对大鼠小肠缺血—再灌注损伤的影响
- Author:
Li ZHANG
;
Linwang DONG
;
Baohong ZHOU
- Publication Type:Journal Article
- Keywords:
cytokines;
interleukin- 8;
en-dothelin;
ischemia-reperfusion;
intestine
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
cDNA of human interleukin-8 was expressed in E. coli bacteria, and recombi-nant human interleukin-8 ( rhIL- 8 ) was produced. The latter was used for treatment of rat intestinal ischemia-reperfusion(I-R) injury, and it was found that rhIL-8 significantly improved the hypotensive state of the animals,and it also inhibited the elevation of plasma endothelin level , decreased the intestinal myeloperoxidase activity, and obviously prolonged the survival timeof the animals. Perfusion of isolated rat superior mesenteric artery with rhIL-8 markedly inhibited endothelin synthesis or (and) release induced by anoxia. The above results suggest that rhIL- 8 may be an effective preventive and therapeutic agent for I-R injury through its inhibition on leukocyte adhesion and endothelin synthesis or (and) release.
