Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse.
- Author:
Se Young JANG
1
;
Han Ik BAE
;
In Kyu LEE
;
Hwan Ki PARK
;
Chang Min CHO
Author Information
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords: Cholangiocarcinoma; Endoscopic ultrasound-guided fine needle aspiration; Individualized medicine; Xenograft
- MeSH: Aged; Animals; Bile Duct Neoplasms/*pathology/surgery; Cholangiocarcinoma/*pathology/surgery; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Heterografts/*pathology/surgery; Humans; Male; Mice; Mice, Nude; Transplantation, Heterologous/*methods
- From:Gut and Liver 2015;9(6):805-808
- CountryRepublic of Korea
- Language:English
- Abstract: Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic agents. We succeeded in generating a patient-derived tumor xenograft of a biliary tumor obtained by endoscopic ultrasound-guided fine-needle aspiration from a patient who had an inoperable extrahepatic cholangiocarcinoma. This patient-derived tumor xenograft will be a promising tool for individualized cancer therapy and can be used in developing new chemotherapeutic agents for the treatment of biliary cancer in the future.
