AUTORADIOGRAPHIC STUDIES OF THE DISTRIBUTION OF〔~(14)C〕PROBIMANE IN MICE
- VernacularTitle:[~(14)C]吗丙嗪在小鼠全身分布的放射自显影
- Author:
Yanping HU
;
Tanmu ZHANG
;
Qingduan WANG
- Publication Type:Journal Article
- Keywords:
〔~(14)C〕Probimane;
Antitumor agent;
Whole body autoradiography;
Tissue distribution
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Probimane was first synthesized and developed in Shanghai Institute of Materia Medica, Chinese Academy of Science as a novel antit umor agent. Male mice were injected iv 〔14C〕 probimane 3.7?105Bq/20g( 5.62? 107Bq/g ) . At 0.5h,higher radioactivities were found in S87 tumor, kidney, bladder, and vertebra, moderate in skim, lung, liver, blood vessel and gut. The radioactivities tended to decre-aseafter 3h except in the tumor, kidney, and gut in which radioactivities persisted. After 12h, only a trace of radioactivity was detected n intestine. The distribution of probimane correlated with its therepeutic efficacy and toxicity.
